Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery.

ABSTRACT:

Background

Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or deterioration after surgery. Enhanced formation of reactive oxygen and nitrogen species accompanies the inflammatory response and triggers separate but integrated reduction/oxidation (redox) pathways that lead to oxidative and/or nitrosative stress (ONS). Quantitative information on ONS in the perioperative period is scarce. This single-centre exploratory study investigated the effects of major surgery on ONS and systemic redox status and their potential associations with postoperative morbidity.

Methods

Blood was collected from 56 patients at baseline, end of surgery (EoS) and the first postoperative day (day-1). Postoperative m

SUBMITTER: Stevens JL 

PROVIDER: S-EPMC10332014 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature