CimpleG: finding simple CpG methylation signatures.
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ABSTRACT:
SUBMITTER: Maie T
PROVIDER: S-EPMC10332104 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
CimpleG: finding simple CpG methylation signatures.
Maié Tiago T Schmidt Marco M Erz Myriam M Wagner Wolfgang W G Costa Ivan I
Genome biology 20230710 1
DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. Here, we propose a computational framework named CimpleG for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. We show that CimpleG is both time efficient and performs as well as top performing methods for cell-type classification of blood cells and other somatic cells, while basing its prediction on a single DNA methylation ...[more]
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