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Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases.

ABSTRACT: Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.

SUBMITTER: Seok JK

PROVIDER: S-EPMC10333371 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases.

Seok Jin Kyung JK Kim Minhyuk M Kang Han Chang HC Cho Yong-Yeon YY Lee Hye Suk HS Lee Joo Young JY

Archives of pharmacal research 20230624 6

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, ...[more]

PMID: 37354378

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