Metagenomic assessment of gut microbial communities and risk of severe COVID-19.

ABSTRACT:

Background

The gut microbiome is a critical modulator of host immunity and is linked to the immune response to respiratory viral infections. However, few studies have gone beyond describing broad compositional alterations in severe COVID-19, defined as acute respiratory or other organ failure.

Methods

We profiled 127 hospitalized patients with COVID-19 (n = 79 with severe COVID-19 and 48 with moderate) who collectively provided 241 stool samples from April 2020 to May 2021 to identify links between COVID-19 severity and gut microbial taxa, their biochemical pathways, and stool metabolites.

Results

Forty-eight species were associated with severe disease after accounting for antibiotic use, age, sex, and various comorbidities. These included significant in-hospital depl

SUBMITTER: Nguyen LH 

PROVIDER: S-EPMC10337137 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature