Ontology highlight
ABSTRACT:
SUBMITTER: Di Molfetta D
PROVIDER: S-EPMC10341693 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Di Molfetta Daria D Cannone Stefania S Greco Maria Raffaella MR Caroppo Rosa R Piccapane Francesca F Carvalho Tiago Miguel Amaral TMA Altamura Concetta C Saltarella Ilaria I Tavares Valente Diana D Desaphy Jean Francois JF Reshkin Stephan J SJ Cardone Rosa Angela RA
International journal of molecular sciences 20230625 13
Intracellular pH (pHi) regulation is a challenge for the exocrine pancreas, where the luminal secretion of bicarbonate-rich fluid is accompanied by interstitial flows of acid. This acid-base transport requires a plethora of ion transporters, including bicarbonate transporters and the Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 (NHE1), which are dysregulated in Pancreatic Ductal Adenocarcinoma (PDAC). PDAC progression is favored by a Collagen-I rich extracellular matrix (ECM) which exacerbat ...[more]