Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations.

ABSTRACT:

Objectives

To compare associations between the Gilbert syndrome genotype in European populations, measured bilirubin concentrations, genetically predicted bilirubin using this genotype, and a wide range of health outcomes in a large cohort.

Design

Cohort study including observational, genetic, and Mendelian randomisation analyses.

Setting

22 centres across England, Scotland, and Wales in UK Biobank (2006-10), with replication in a national Finnish cohort (FinnGen).

Participants

463 060 participants in the UK Biobank were successfully genotyped for a genetic variant (rs887829) that is strongly associated with Gilbert syndrome and 438 056 participants had measured bilirubin concentrations with linked electronic health record data coded using the tenth edition of

SUBMITTER: Hamilton FW 

PROVIDER: S-EPMC10347488 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature