Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum.

ABSTRACT: Periodontitis is the most important cause of tooth loss in adults and is closely related to various systemic diseases. Its etiologic factor is plaque biofilm, and the primary treatment modality is plaque control. Studies have confirmed that Fusobacterium nucleatum can cause periodontitis through its virulence factors and copolymerizing effects with other periodontal pathogens, such as the red complex. Inhibiting F. nucleatum is an essential target for preventing periodontitis. The time-consuming and costly traditional periodontal treatment, periodontal scaling, and root planing are a significant burden on individual and public health. Antibiotic use may lead to oral microbial resistance and microbiome imbalance, while probiotics regulate microbial balance. Akkermansia muciniphila is a crit

SUBMITTER: Song B 

PROVIDER: S-EPMC10352368 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature