Ontology highlight
ABSTRACT:
SUBMITTER: Bernard Q
PROVIDER: S-EPMC10358927 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Bernard Quentin Q Goumeidane Maïssa M Chaumond Emmanuel E Robbe-Saule Marie M Boucaud Yan Y Esnault Lucille L Croué Anne A Jullien Jerome J Marsollier Laurent L Marion Estelle E
PLoS pathogens 20230710 7
Buruli ulcer is a chronic infectious disease caused by Mycobacterium ulcerans. The pathogen persistence in host skin is associated with the development of ulcerative and necrotic lesions leading to permanent disabilities in most patients. However, few of diagnosed cases are thought to resolve through an unknown self-healing process. Using in vitro and in vivo mouse models and M. ulcerans purified vesicles and mycolactone, we showed that the development of an innate immune tolerance was only spec ...[more]