The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases.

ABSTRACT: The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier separating the blood and the tissues in several organs. ECs maintain endothelium integrity by controlling the constriction and relaxation of the vasculature, blood fluidity, adhesion, and migration. These actions of ECs are efficiently coordinated via an intricate signaling network connecting receptors, and a wide range of cellular macromolecules. ECs are naturally quiescent i.e.; they are not stimulated and do not proliferate. Upon infection or disease, ECs become activated, and this alteration is pivotal in the pathogenesis of a spectrum of human neurological, cardiovascular, diabetic, cancerous, and viral diseases. Considering the central position that ECs play in disease pathogenesis, therapeutic

SUBMITTER: Adetunji JA 

PROVIDER: S-EPMC10361329 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature