High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death.

ABSTRACT: Oral and intestinal mucositis (OIM) are debilitating inflammatory diseases initiated by oxidative stress, resulting in epithelial cell death and are frequently observed in cancer patients undergoing chemo-radiotherapy. There are currently few preventative strategies for this debilitating condition. Therefore, the development of a safe and effective mucositis mitigating strategy is an unmet medical need. Hyaluronic acid (HA) preparations have been tentatively used in oral mucositis. However, the protective effects of HA in chemotherapy-induced mucositis and their underlying mechanisms remain to be fully elucidated. This study aimed to assess these mechanisms using multiple formulations of enriched HA (Mucosamin^®), cross-linked (xl-), and non-crosslinked high molecular weight HA (

SUBMITTER: Mohammed AI 

PROVIDER: S-EPMC10362044 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature