Behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica.

ABSTRACT:

Introduction

Variability in household secondary attack rates and transmission risks factors of SARS-CoV-2 remain poorly understood.

Methods

We conducted a household transmission study of SARS-CoV-2 in Costa Rica, with SARS-CoV-2 index cases selected from a larger prospective cohort study and their household contacts were enrolled. A total of 719 household contacts of 304 household index cases were enrolled from November 21, 2020, through July 31, 2021. Blood specimens were collected from contacts within 30-60 days of index case diagnosis; and serum was tested for presence of spike and nucleocapsid SARS-CoV-2 IgG antibodies. Evidence of SARS-CoV-2 prior infections among household contacts was defined based on the presence of both spike and nucleocapsid antibodies. We fitted a

SUBMITTER: Sun K 

PROVIDER: S-EPMC10363136 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature