Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study.

ABSTRACT:

Background

A machine-learning approach identified five subgroups of diabetes in Europeans which included severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) with partially distinct genetic aetiologies. We previously validated four of the non-autoimmune subgroups in people with young-onset type 2 diabetes (T2D) from the Indian WellGen study. Here, we aimed to apply European-derived centroids and genetic risk scores (GRSs) to the unselected (for age) WellGen to test their applicability and investigate the genetic aetiology of the Indian T2D subgroups.

Methods

We applied European derived centroids and GRSs to T2D participants of Indian ance

SUBMITTER: Yajnik CS 

PROVIDER: S-EPMC10363502 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature