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Ferroptosis as a potential target for cancer therapy.

ABSTRACT: Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.

SUBMITTER: Chen Z

PROVIDER: S-EPMC10366218 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Ferroptosis as a potential target for cancer therapy.

Chen Zhen Z Wang Weilong W Abdul Razak Siti Razila SR Han Tao T Ahmad Nor Hazwani NH Li Xiumin X

Cell death & disease 20230724 7

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its d ...[more]

PMID: 37488128

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