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Ferroptosis: An Emerging Target for Bladder Cancer Therapy.

ABSTRACT: Bladder cancer (BC), as one of the main urological cancers in the world, possesses the abilities of multiple-drug resistance and metastasis. However, there remains a significant gap in the understanding and advancement of prognosis and therapeutic strategies for BC. Ferroptosis, a novel type of iron-dependent regulated cell death, depends on lipid peroxidation, which has been proven to have a strong correlation with the development and treatment of BC. Its mechanism mainly includes three pathways, namely, lipid peroxidation, the antioxidant system, and the iron overload pathway. In this review, we reviewed the mechanism of ferroptosis, along with the related therapeutic targets and drugs for BC, as it might become a new anticancer treatment in the future.

SUBMITTER: Shan Z

PROVIDER: S-EPMC10605744 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Ferroptosis: An Emerging Target for Bladder Cancer Therapy.

Shan Zhengda Z Tang Wenbin W Shi Zhiyuan Z Shan Tao T

Current issues in molecular biology 20231010 10

Bladder cancer (BC), as one of the main urological cancers in the world, possesses the abilities of multiple-drug resistance and metastasis. However, there remains a significant gap in the understanding and advancement of prognosis and therapeutic strategies for BC. Ferroptosis, a novel type of iron-dependent regulated cell death, depends on lipid peroxidation, which has been proven to have a strong correlation with the development and treatment of BC. Its mechanism mainly includes three pathway ...[more]

PMID: 37886960

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