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Defueling the cancer: ATP synthase as an emerging target in cancer therapy.

ABSTRACT: Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in glioblastoma, ovarian cancer, prostate cancer, breast cancer, and clear cell renal cell carcinoma. Cell surface-expressed ATP synthase, translocated from mitochondrion to cell membrane, involves the angiogenesis, tumorigenesis, and metastasis of cancer. ATP synthase has therefore been considered a therapeutic target. We review recent various ATP synthase inhibitors that suppress tumor growth and are being tested for the clinic.

SUBMITTER: Wang T

PROVIDER: S-EPMC8517097 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Defueling the cancer: ATP synthase as an emerging target in cancer therapy.

Wang Ting T Ma Fei F Qian Hai-Li HL

Molecular therapy oncolytics 20210903

Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in glioblastoma, ovarian cancer, prostate cancer, breast cancer, and clear cell renal cell carcinoma. Cell surface-expressed ATP synthase, translocated from mitochondrion to cell membrane, involves the angiogenesis, tumorigenesis, and metastasis of cancer ...[more]

PMID: 34703878

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