Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns.

ABSTRACT: Staphylococcus epidermidis and Staphylococcus aureus are highly problematic bacteria in hospital settings. A major challenge is their ability to form biofilms on abiotic or biotic surfaces. Biofilms are well-organized, multicellular bacterial aggregates that resist antibiotic treatment and often lead to recurrent infections. Bacterial cell wall-anchored (CWA) proteins are important players in biofilm formation and infection. Many have putative stalk-like regions or regions of low complexity near the cell wall-anchoring motif. Recent work demonstrated the strong propensity of the stalk region of S. epidermidis accumulation-associated protein (Aap) to remain highly extended under solution conditions that typically induce compaction. This behavior is consistent with the expected function of a

SUBMITTER: Yarawsky AE 

PROVIDER: S-EPMC10367597 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature