Binding modes of potential anti-prion phytochemicals to PrP^C structures in silico.

ABSTRACT:

Background

Prion diseases involve the conversion of a normal, cell-surface glycoprotein (PrP^C) into a misfolded pathogenic form (PrP^Sc). One possible strategy to inhibit PrP^Sc formation is to stabilize the native conformation of PrP^C and interfere with the conversion of PrP^C to PrP^Sc. Many compounds have been shown to inhibit the conversion process, however, no promising drugs have been identified to cure prion diseases.

Objective

This study aims to identify potential anti-prion compounds from plant phytochemicals by integrating traditional ethnobotanical knowledge with modern in silico drug design approaches.

Materials and methods

In the current study medicinal phytochemicals were docked with swapped a

SUBMITTER: Neupane S 

PROVIDER: S-EPMC10368899 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature