Epidermal growth factor rs4444903 polymorphism and risk of cholangiocarcinoma. A case control study.

ABSTRACT:

Aim of the study

Cholangiocarcinoma (CCA) comprises a diverse group of malignancies that occur anywhere along the biliary tree. Gene polymorphisms are risk factors for CCA development. Expression levels of epidermal growth factor (EGF) are correlated with progressive tumor growth and metastasis by increasing tumor cell proliferation and migration. The EGF rs4444903 (G) allele seems to enhance carcinogenesis in several types of cancer. The aim was to study the association between epidermal growth factor EGF (rs4444903) gene polymorphism and risk of CCA in Egyptian patients.

Material and methods

This case-control study included 100 subjects, 50 CCA patients and 50 healthy individuals as controls. The EGF (rs4444903) genotyping was performed by real-time polymerase chain reacti

SUBMITTER: Gawish EA 

PROVIDER: S-EPMC10369652 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature