SURROGATE SELECTION OVERSAMPLES EXPANDED T CELL CLONOTYPES.

ABSTRACT: Inference from immunological data on cells in the adaptive immune system may benefit from modeling specifications that describe variation in the sizes of various clonal sub-populations. We develop one such specification in order to quantify the effects of surrogate selection assays, which we confirm may lead to an enrichment for amplified, potentially disease-relevant T cell clones. Our specification couples within-clonotype birth-death processes with an exchangeable model across clonotypes. Beyond enrichment questions about the surrogate selection design, our framework enables a study of sampling properties of elementary sample diversity statistics; it also points to new statistics that may usefully measure the burden of somatic genomic alterations associated with clonal expansion. We exa

SUBMITTER: Yu P 

PROVIDER: S-EPMC10369934 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature