Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study.

ABSTRACT:

Aims

There is still no non-invasive septal reduction therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to investigate the feasibility, safety, and efficacy of stereotactic body radiotherapy (SBRT) in patients with drug-refractory symptomatic HOCM.

Methods and results

The radiation target of ventricular septum was determined by multiple anatomical imaging. Stereotactic body radiotherapy was performed with standard techniques. Patients were treated with a single fraction of 25 Gy, followed up at 1, 3, 6, and 12 months by clinical visit. Five patients were enrolled and completed the 12 months follow-up. The mean radioablation time was 21.6 min, and the mean target volume was 10.5 cm³. All five patients survived and showed impr

SUBMITTER: Li X 

PROVIDER: S-EPMC10371052 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature