The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs have been shown to inhibit the development of induced neoplasms. Our previous research demonstrated that the cytotoxicity of sulindac against melanoma cells is comparable to dacarbazine, the drug used in chemotherapy. The aim of this study was to investigate the mechanism of sulindac cytotoxicity on COLO 829 and C32 cell lines.

Methods

The influence of sundilac on the activity of selected enzymes of the antioxidant system (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and the content of hydrogen peroxide as well as the level of proteins initiating (p53, Bax) and inhibiting (Bcl-2) apoptosis were measured in melanoma cells.

Results

In melanotic melanoma cells, sulindac increased the activi

SUBMITTER: Milinski M 

PROVIDER: S-EPMC10374796 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature