Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
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ABSTRACT:
SUBMITTER: Rauth S
PROVIDER: S-EPMC10374878 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
Rauth Sanchita S Ganguly Koelina K Atri Pranita P Parte Seema S Nimmakayala Rama Krishna RK Varadharaj Venkatesh V Nallasamy Palanisamy P Vengoji Raghupathy R Ogunleye Ayoola O AO Lakshmanan Imayavaramban I Chirravuri Ramakanth R Bessho Mika M Cox Jesse L JL Foster Jason M JM Talmon Geoffrey A GA Bessho Tadayoshi T Ganti Apar Kishor AK Batra Surinder K SK Ponnusamy Moorthy P MP
Cell reports 20230128 2
Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human cancers (ovarian, lung, and pancreas). Mechanistically, cisplatin- and gemcitabine-resistant cells show enhanced DNA repair, which is inhibited by PAF1 silencing. We demonstrate an increased interaction ...[more]
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