The complex genomic diversity of Yersinia pestis on the long-term plague foci in Qinghai-Tibet plateau.

ABSTRACT: Plague is a typical natural focus disease that circulates in different ecology of vectors and reservoir hosts. We conducted genomic population and phylogenetic analyses of the Yersinia pestis collected from the 12 natural plague foci in China with more than 20 kinds of hosts and vectors. Different ecological landscapes with specific hosts, vectors, and habitat which shape various niches for Y. pestis. The phylogeographic diversity of Y. pestis in different kinds plague foci in China showed host niches adaptation. Most natural plague foci strains are region-and focus-specific, with one predominant subpopulation; but the isolates from the Qinghai-Tibet plateau harbor a higher genetic diversity than other foci. The Y. pestis from Marmota himalayana plague fo

SUBMITTER: Liang J 

PROVIDER: S-EPMC10375460 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature