A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression.
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ABSTRACT:
SUBMITTER: Sharlo KA
PROVIDER: S-EPMC10378404 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression.
Sharlo Kristina A KA Lvova Irina D ID Tyganov Sergey A SA Sergeeva Ksenia V KV Kalashnikov Vitaly Y VY Kalashnikova Ekaterina P EP Mirzoev Timur M TM Kalamkarov Grigoriy R GR Shevchenko Tatiana F TF Shenkman Boris S BS
Current issues in molecular biology 20230630 7
Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, po ...[more]
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