αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading.
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ABSTRACT:
SUBMITTER: Willey JS
PROVIDER: S-EPMC9163032 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading.
Willey Jeffrey S JS Aunon-Chancellor Serena S Miles Lauren A LA Moore Joseph E JE Mao Xiao W XW Wallace Robert W RW Foy Matthew C MC
NPJ microgravity 20220602 1
Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU. ...[more]
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