Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses.

ABSTRACT: Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10383046 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature