Synthesis, Biological, Spectroscopic and Computational Investigations of Novel <i>N</i>-Acylhydrazone Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone as Dual COX/LOX Inhibitors.

ABSTRACT: Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-d]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety is a privileged structure occurring in many promising drug candidates, we decided to introduce this pharmacophore into new series of pyrrolo[3,4-d]pyridazinone derivatives. The current paper presents the synthesis and in vitro, spectroscopic, and in silico studies evaluating the biological and physicochemical properties of NAH deriv

SUBMITTER: Mikus J 

PROVIDER: S-EPMC10383271 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature