Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine.

ABSTRACT: African swine fever (ASF) is a highly contagious disease that affects wild and domestic swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia and the Caribbean region. The etiological agent of ASF is a large, highly complex structural virus (ASFV) harboring a double-stranded genome encoding for more than 160 proteins whose functions, in most cases, have not been experimentally characterized. We show here that deletion of the ASFV gene H240R from the genome of the highly virulent ASFV-Georgia2010 (ASFV-G) isolate partially decreases virus virulence when experimentally inoculated in domestic swine. ASFV-G-∆H240R, a recombinant virus harboring the deletion of the H240R gene, was produced to evaluate the function of the gene in the developmen

SUBMITTER: Ramirez-Medina E 

PROVIDER: S-EPMC10384018 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature