Objective measures of reward sensitivity and motivation in people with high v. low anhedonia.

ABSTRACT:

Background

Anhedonia - a diminished interest or pleasure in activities - is a core self-reported symptom of depression which is poorly understood and often resistant to conventional antidepressants. This symptom may occur due to dysfunction in one or more sub-components of reward processing: motivation, consummatory experience and/or learning. However, the precise impairments remain elusive. Dissociating these components (ideally, using cross-species measures) and relating them to the subjective experience of anhedonia is critical as it may benefit fundamental biology research and novel drug development.

Methods

Using a battery of behavioural tasks based on rodent assays, we examined reward motivation (Joystick-Operated Runway Task, JORT; and Effort-Expenditure for Rewards T

SUBMITTER: Slaney C 

PROVIDER: S-EPMC10388304 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature