Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa.

ABSTRACT:

Introduction

The primary goal of this work is to broaden and enhance the options for induction of protective CD8⁺ T cells against HIV-1 and respiratory pathogens.

Methods

We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combination with the in-human potent regimen of simian adenovirus ChAdOx1 prime-poxvirus MVA boost delivering bi-valent mosaic of HIV-1 conserved regions designated HIVconsvX.

Results

We showed in BALB/c mice that the PIV5 vector expressing the HIVconsvX immunogens could be readily incorporated with the other two vaccine modalities into a single regimen and that for specific vector combinations, mucosal CD8⁺ T-cell induction was enhanced synergistically

SUBMITTER: Beavis AC 

PROVIDER: S-EPMC10390215 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature