Computational drug discovery under RNA times.
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ABSTRACT:
SUBMITTER: Bernetti M
PROVIDER: S-EPMC10392680 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Computational drug discovery under RNA times.
Bernetti Mattia M Aguti Riccardo R Bosio Stefano S Recanatini Maurizio M Masetti Matteo M Cavalli Andrea A
QRB discovery 20221114
RNA molecules play many functional and regulatory roles in cells, and hence, have gained considerable traction in recent times as therapeutic interventions. Within drug discovery, structure-based approaches have successfully identified potent and selective small-molecule modulators of pharmaceutically relevant protein targets. Here, we embrace the perspective of computational chemists who use these traditional approaches, and we discuss the challenges of extending these methods to target RNA mol ...[more]
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