The significance of central blood pressure for cardiovascular target organ damage in children and adolescents after kidney transplantation.

ABSTRACT:

Background

Cardiovascular (CV) complications are important causes of morbidity and mortality in children after kidney transplantation (KTx). In adults, central blood pressure (cBP) is an accepted predictor of CV sequelae. We aimed to assess the prognostic value of cBP over peripheral blood pressure (pBP) for existing CV damage.

Methods

We measured cBP and pBP in 48 pediatric KTx recipients (mean age: 13.5 ± 4.2 years). Assessment of left ventricular mass index (LVMI) and aortic pulse wave velocity (PWV) allowed detection of CV target organ damage. LVMI and PWV were used as endpoints in multivariable linear regression models, in which cBP and pBP were compared for their predictive value.

Results

Using cBP z-scores, we identified a larger number of patients with uncontr

SUBMITTER: Greiner AS 

PROVIDER: S-EPMC10393860 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature