Ontology highlight
ABSTRACT:
SUBMITTER: Ding D
PROVIDER: S-EPMC10400651 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Nature communications 20230803 1
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence accelerates prostatic oncogenesis. p53 gain-of-function (GOF) mutants are now shown to bind to a unique DNA sequence in the CTNNB1 gene promoter and transactivate its expression. ERG and β-Catenin co-occupy sites at pyrimidine synthesis gene (PSG) loci and p ...[more]