Slo1 deficiency impaired skeletal muscle regeneration and slow-twitch fibre formation.

ABSTRACT:

Background

It has been observed that Slo1 knockout mice have reduced motor function, and people with certain Slo1 mutations have movement problems, but there is no answer whether the movement disorder is caused by the loss of Slo1 in the nervous system, or skeletal muscle, or both. Here, to ascertain in which tissues Slo1 functions to regulate motor function and offer deeper insight in treating related movement disorder, we generated skeletal muscle-specific Slo1 knockout mice, studied the functional changes in Slo1-deficient skeletal muscle and explored the underlying mechanism.

Methods

We used skeletal muscle-specific Slo1 knockout mice (Myf5-Cre; Slo1^flox/flox mice, called CKO) as in vivo models to examine the role of Slo1 in muscle growth and muscle regenerati

SUBMITTER: Xia C 

PROVIDER: S-EPMC10401544 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature