Spermatogenesis after gonadotoxic childhood treatment: follow-up of 12 patients.

ABSTRACT:

Study question

What is the long-term impact of presumed gonadotoxic treatment during childhood on the patient's testicular function at adulthood?

Summary answer

Although most patients showed low testicular volumes and some degree of reproductive hormone disruption 12.3 (2.3-21.0) years after gonadotoxic childhood therapy, active spermatogenesis was demonstrated in the semen sample of 8 out of the 12 patients.

What is known already

In recent decades, experimental testicular tissue banking programmes have been set up to safeguard the future fertility of young boys requiring chemo- and/or radiotherapy with significant gonadotoxicity. Although the risk of azoospermia following such therapies is estimated to be high, only limited long-term data are available on the reprodu

SUBMITTER: Delgouffe E 

PROVIDER: S-EPMC10403430 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature