Proteomic Analysis of Testicular Interstitial Fluid in Men with Azoospermia.

ABSTRACT:

Background

The primary microenvironment of the testis comprises testicular interstitial fluid (TIF) surrounding the seminiferous tubules and testicular interstitial tissue. The pathological alterations of germ and Sertoli cells could affect the TIF composition and might contain putative biomarkers for monitoring active spermatogenesis.

Objective

We identified differentially expressed proteins in the TIF of patients with obstructive (OA) or nonobstructive (NOA) azoospermia to elucidate the underlying etiology of defective spermatogenesis.

Design setting and participants

We prospectively enrolled nine patients, including three men with OA and six with NOA with (n = 3) and without (n = 3) successful sperm retrieval. Their TIF was collected during the testic

SUBMITTER: Huang IS 

PROVIDER: S-EPMC10403685 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature