Switching carbon metabolic flux for enhancing the production of sesquiterpene-based high-density biofuel precursor in Saccharomyces cerevisiae.

ABSTRACT:

Background

Sesquiterpenes are designated as a large class of plant-derived natural active compounds, which have wide applications in industries of energy, food, cosmetics, medicine and agriculture. Neither plant extraction nor chemical synthesis can meet the massive market demands and sustainable development goals. Biosynthesis in microbial cell factories represents an eco-friendly and high-efficient way. Among several microorganisms, Saccharomyces cerevisiae exhibited the potential as a chassis for bioproduction of various sesquiterpenes due to its native mevalonate pathway. However, its inefficient nature limits biosynthesis of diverse sesquiterpenes at industrial grade.

Results

Herein, we exploited an artificial synthetic malonic acid-acetoacetyl-CoA (MAAC) metabolic path

SUBMITTER: Liang B 

PROVIDER: S-EPMC10403917 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature