Comparative proteomics in captive giant pandas to identify proteins involved in age-related cataract formation.

ABSTRACT: Approximately 20% of aged captive giant pandas (Ailuropoda melanoleuca) have cataracts that impair their quality of life. To identify potential biomarkers of cataract formation, we carried out a quantitative proteomics analysis of 10 giant pandas to find proteins differing in abundance between healthy and cataract-bearing animals. We identified almost 150 proteins exceeding our threshold for differential abundance, most of which were associated with GO categories related to extracellular localization. The most significant differential abundance was associated with components of the proteasome and other proteins with a role in proteolysis or its regulation, most of which were depleted in pandas with cataracts. Other modulated proteins included components of the extracellular matrix or cytos

SUBMITTER: You Y 

PROVIDER: S-EPMC10404263 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature