Barrier films for the prevention of acute radiation dermatitis in breast cancer: A systematic review and meta-analysis of randomised controlled trials.

ABSTRACT:

Purpose

Radiation dermatitis (RD) is the most common side effect of adjuvant whole-breast or chest wall irradiation, majorly impacting quality of life in numerous patients. The use of barrier films (polyurethane dressings such as Hydrofilm® and Mepitel® film remaining on the skin for the duration of the radiation treatment) has been investigated as a prophylactic measure in several prospective trials. Here, we critically appraise the available evidence behind preventive barrier film application in the context of breast cancer treatment.

Methods

International literature was reviewed and high-quality randomised controlled trials (RCTs) were included in this meta-analysis.

Results

The results of 5 RCTs (663 patients; >90% Caucasian) were analysed. Overall, barrier films

SUBMITTER: Dejonckheere CS 

PROVIDER: S-EPMC10404536 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature