Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.

ABSTRACT:

Background

Newborns with prenatal opioid exposure (POE) are commonly diagnosed with neonatal abstinence/opioid-withdrawal syndromes due to characteristic symptoms and overt behaviors. However, little is known about the underlying physiology of opioid-exposed newborns.

Objective

Cardiac, respiratory and movement activity were measured to identify physiologic dysregulation and quantify pathophysiologic instabilities of the central and autonomic nervous systems in POE newborns.

Methods

In this pilot study, 30 hospitalized POE newborns (>35 wks gestational age) participated in one of two study phases wherein physiologic activity was measured for an 8-10 h session. In Phase 1, 17 infants received usual treatment to provide a general assessment of physiologic activity. In P

SUBMITTER: Bloch-Salisbury E 

PROVIDER: S-EPMC10405740 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature