Ontology highlight
ABSTRACT:
SUBMITTER: Chin CS
PROVIDER: S-EPMC10406601 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Chin Chen-Shan CS Behera Sairam S Khalak Asif A Sedlazeck Fritz J FJ Sudmant Peter H PH Wagner Justin J Zook Justin M JM
Nature methods 20230626 8
Advancements in sequencing technologies and assembly methods enable the regular production of high-quality genome assemblies characterizing complex regions. However, challenges remain in efficiently interpreting variation at various scales, from smaller tandem repeats to megabase rearrangements, across many human genomes. We present a PanGenome Research Tool Kit (PGR-TK) enabling analyses of complex pangenome structural and haplotype variation at multiple scales. We apply the graph decomposition ...[more]