Global effects of identity and aging on the human sperm methylome.

ABSTRACT:

Background

As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact offspring. Age-associated change to DNA cytosine methylation in the cytosine-guanine (CpG) context is a hallmark of aging tissues, including sperm. Prior studies have led to accurate models that predict a man's age based on specific methylation features in the DNA of sperm, but the relationship between aging and global DNA methylation in sperm remains opaque. Further clarification requires a more complete survey of the methylome with assessment of variability within and between individuals.

Results

We collected sperm methylome data in a longitudinal study of ten healthy

SUBMITTER: de Sena Brandine G 

PROVIDER: S-EPMC10408082 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature