Dataset Information

Post-COVID-19 illness and associations with sex and gender.

ABSTRACT:

Background

Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.

Aim

There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.

Design

This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence.

Methods

Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28-60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization.

Results

Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28-60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018).

Conclusions

Women demonstrated worse patient reported outcome measures at index admission and 28-60 days follow-up though cardiovascular hospitalization was lower.

SUBMITTER: Mangion K

PROVIDER: S-EPMC10408208 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Post-COVID-19 illness and associations with sex and gender.

Mangion Kenneth K Morrow Andrew J AJ Sykes Robert R Kamdar Anna A Bagot Catherine C Bruce George G Connelly Paul P Delles Christian C Gibson Vivienne B VB Gillespie Lynsey L Barrientos Pauline Hall PH Lennie Vera V Roditi Giles G Sattar Naveed N Stobo David D Allwood-Spiers Sarah S McConnachie Alex A Berry Colin C

BMC cardiovascular disorders 20230808 1

<h4>Background</h4>Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.<h4>Aim</h4>There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.<h4>Design</h4>This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence.<h4>Methods</h4>Clinical informat ...[more]

PMID: 37553628

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Project description:BackgroundDuring the course of the COVID-19 pandemic, states were called upon by the World Health Organization to introduce and prioritise the collection of sex-disaggregated data. The collection of sex-disaggregated data on COVID-19 testing, infection rates, hospital admissions, and deaths, when available, has informed our understanding of the biology of the infectious disease. The collection of sex-disaggregated data should also better inform our understanding of the gendered impacts that contribute to risk of exposure to COVID-19. In China, the country with the longest history of fighting the COVID-19 infection, what research was available on the gender-differential impacts of COVID-19 in the first 6 months of the COVID-19 pandemic?MethodsIn this scoping review, we examine the first 6 months (January-June 2020) of peer-reviewed publications (n = 451) on sex and gender experiences related to COVID-19 in China. We conducted an exhaustive search of published Chinese and English language research papers on COVID-19 in mainland China. We used a COVID-19 Gender Matrix informed by the JPHIEGO gender analysis toolkit to examine and illuminate research into the gendered impacts of COVID-19 within China.ResultsIn China, only a small portion of the COVID-19-related research focused on gender experiences and differences. Near the end of the six-month literature review period, a small number of research items emerged on women healthcare workers, women's mental health, and pregnant women's access to care. There was an absence of research on the gendered impact of COVID-19 amongst populations. There was minimal consideration of the economic, social and security factors, including gender stereotypes and expectations, that affected different populations' experiences of infection, treatment, and lockdown during the period of review.ConclusionAt the outset of health emergencies in China, gender research needs to be prioritised during the first stage of an outbreak to assist with evaluation of the most effective public health measures, identifying access to healthcare and social welfare barriers amongst priority communities. Gender stereotypes and gendered differences lead to different patterns of exposure and treatment. The exclusion of this knowledge in real time affects the design of effective prevention and recovery.

Dataset Information

Post-COVID-19 illness and associations with sex and gender.

Background

Aim

Design

Methods

Results

Conclusions

Publications

Post-COVID-19 illness and associations with sex and gender.

Similar Datasets

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