Peptidyl arginine deiminase inhibition alleviates angiotensin II-induced fibrosis.

ABSTRACT:

Objectives

The conversion of protein arginine residues to citrulline by calcium-dependent peptidyl arginine deiminases (PADs) has been implicated in the pathogenesis of several diseases, indicating that PADs are therapeutic targets. A recent study indicated that PAD4 regulates age-related organ fibrosis and dysfunction; however, the specific role of this PAD and its citrullination substrate remains unclear. We investigated whether pharmacological inhibition of PAD activity could affect the progression of fibrosis and restore heart function.

Methods

Cardiac hypertrophy was induced by chronic infusion of angiotensin (Ang) II. After 2 weeks of AngII infusion, a PAD inhibitor (Cl-amidine hydrochloride) or vehicle (saline) was injected every other day for the next 14 days togethe

SUBMITTER: Ijichi T 

PROVIDER: S-EPMC10408542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature