Dataset Information

Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies.

ABSTRACT:

Introduction

Maternal vitamin D status during pregnancy has been suggested to have a role in childhood adiposity development, but results are conflicting. Our aims were to investigate [1] the relationships between maternal 25-hydroxyvitamin D (25OHD) during pregnancy and the child's body mass index (BMI) and risk of overweight at 5 years of age, and [2] maternal pre-pregnancy BMI as effect modifier for these associations.

Methods

Data sources included a subsample from the Norwegian Mother, Father and Child Cohort Study (MoBa sub-cohort; N = 2,744) and the Swedish GraviD cohort study (N = 891). Maternal 25OHD was analyzed in gestational week 18 in the MoBa sub-cohort and week 10 in the GraviD cohort. In the MoBa sub-cohort, parents reported their child's documented measures of weight and length or height from the health card at routine check-up. In the GraviD cohort, this information was collected directly from medical records. Childhood overweight (including obesity) was identified using the International Obesity Task Force cut-offs. Linear and logistic regression models were used to investigate the association between maternal 25OHD and child's BMI and risk of overweight at 5 years of age in each cohort separately, and in a pooled dataset.

Results

In the pooled analysis, maternal 25OHD <30 nmol/L was associated with lower BMI in children at 5 years of age, but not with risk of overweight. Interaction analysis showed that the association was predominant among children of mothers with pre-pregnancy BMI ≥25 kg/m².

Conclusion

Low maternal vitamin D status, particularly in mothers with overweight or obesity, predicted lower BMI in their five-year-old children. However, there was no evidence of an effect on overweight in these children.

SUBMITTER: Amberntsson A

PROVIDER: S-EPMC10410266 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies.

Amberntsson Anna A Bärebring Linnea L Winkvist Anna A Lissner Lauren L Meltzer Helle Margrete HM Brantsæter Anne Lise AL Papadopoulou Eleni E Augustin Hanna H

Frontiers in nutrition 20230726

<h4>Introduction</h4>Maternal vitamin D status during pregnancy has been suggested to have a role in childhood adiposity development, but results are conflicting. Our aims were to investigate [1] the relationships between maternal 25-hydroxyvitamin D (25OHD) during pregnancy and the child's body mass index (BMI) and risk of overweight at 5 years of age, and [2] maternal pre-pregnancy BMI as effect modifier for these associations.<h4>Methods</h4>Data sources included a subsample from the Norwegia ...[more]

PMID: 37565036

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Dataset Information

Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies.

Introduction

Methods

Results

Conclusion

Publications

Maternal vitamin D status and risk of childhood overweight at 5 years of age in two Nordic cohort studies.

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