Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis.

ABSTRACT:

Background

Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Notably, individuals with these illnesses also have major disruptions in sleep and circadian rhythms, and disturbances of sleep and circadian rhythms can precipitate or exacerbate psychotic symptoms. Psychosis is associated with the striatum, though to our knowledge, no study to date has directly measured molecular rhythms and determined how they are altered in the striatum of subjects with psychosis.

Methods

We performed RNA sequencing and both differential expression and rhythmicity analyses to investigate diurnal alterations in gene expression in human postmortem striatal subregions (nucleus accumbens, caudate, and putamen) in subjects with psychosis (n = 36) relative to

SUBMITTER: Ketchesin KD 

PROVIDER: S-EPMC10411997 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature