COVID-19 and the risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study.

ABSTRACT:

Background

An increasing number of studies have elucidated a close nexus between COVID-19 phenotypes and neuromyelitis optica spectrum disorder (NMOSD), yet the causality between them remains enigmatic.

Methods

In this study, we conducted a Mendelian randomization (MR) analysis employing summary data sourced from genome-wide association studies (GWAS) pertaining to COVID-19 susceptibility, hospitalization, severity, and NMOSD. The primary MR analysis employed the Inverse variance weighted (IVW) approach, which was supplemented by MR-Egger, weighted median, simple mode, and weighted mode methods. We implemented various sensitivity analyses including Cochran's Q test, MR-PRESSO method, MR-Egger intercept, leave-one-out analysis, and funnel plot.

Results

The MR results d

SUBMITTER: Sun D 

PROVIDER: S-EPMC10414539 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature