The association between white matter tract structural connectivity and information processing speed in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Information processing speed (IPS) deterioration is common in relapsing-remitting multiple sclerosis (RRMS) patients [1] and might severely affect quality of life and occupational activity. However, understanding of its neural substrate is not fully elucidated. We aimed to investigate the associations between MRI-derived metrics of neuroanatomical structures, including the tracts, and IPS.

Methods

Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and Color Trails Test (CTT) were used to evaluate IPS in 73 RRMS consecutive patients, all undergoing only interferon beta (IFN-β) therapy during the study. At the same time, 1.5T MRI including diffusion tensor imaging (DTI) data was acquired for each recruited subject. We analyzed volumetr

SUBMITTER: Chylinska M 

PROVIDER: S-EPMC10415523 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature