Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias.
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ABSTRACT: Introduction
Neural circuit alterations lay at the core of brain physiopathology, and yet are hard to unveil in living subjects. The Virtual Brain (TVB) modeling, by exploiting structural and functional magnetic resonance imaging (MRI), yields mesoscopic parameters of connectivity and synaptic transmission.Methods
We used TVB to simulate brain networks, which are key for human brain function, in Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients, whose connectivity and synaptic parameters remain largely unknown; we then compared them to healthy controls, to reveal novel in vivo pathological hallmarks.Results
The pattern of simulated parameter differed between AD and FTD, shedding light on disease-specific alterations in brain networks. Individual subjects displayed subtle differences in network parameter patterns that significantly correlated with their individual neuropsychological, clinical, and pharmacological profiles.Discussion
These TVB simulations, by informing about a new personalized set of networks parameters, open new perspectives for understanding dementias mechanisms and design personalized therapeutic approaches.
SUBMITTER: Monteverdi A
PROVIDER: S-EPMC10419271 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias.
Monteverdi Anita A Palesi Fulvia F Schirner Michael M Argentino Francesca F Merante Mariateresa M Redolfi Alberto A Conca Francesca F Mazzocchi Laura L Cappa Stefano F SF Cotta Ramusino Matteo M Costa Alfredo A Pichiecchio Anna A Farina Lisa M LM Jirsa Viktor V Ritter Petra P Gandini Wheeler-Kingshott Claudia A M CAM D'Angelo Egidio E
Frontiers in aging neuroscience 20230728
<h4>Introduction</h4>Neural circuit alterations lay at the core of brain physiopathology, and yet are hard to unveil in living subjects. The Virtual Brain (TVB) modeling, by exploiting structural and functional magnetic resonance imaging (MRI), yields mesoscopic parameters of connectivity and synaptic transmission.<h4>Methods</h4>We used TVB to simulate brain networks, which are key for human brain function, in Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients, whose connectivi ...[more]
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