Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts.

ABSTRACT:

Background

Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown.

Methods

We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO₂), fine particles (PM_2.5), black carbon (BC), ozone (O₃) and eight elemental components of PM_2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0-191.9/C71.0-C71.9, 192.0/C72.2-C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.

Results

During 5,497,514 person-ye

SUBMITTER: Hvidtfeldt UA 

PROVIDER: S-EPMC10421949 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature